Varaico: Literature-Extracted Genetic Variants

MSH3

1,102 papers

RefSeq Summary

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch ...

Pfam Domains

MutS_Iaa 230–343UCSCMutS domain I

MutS_IIaa 366–523UCSCMutS domain II

MutS_IIIaa 540–838UCSCMutS domain III

MutS_Vaa 892–1094UCSCMutS domain V

Gene Aliases

HGNC Name

mutS homolog 3

HGNC Alias Symbols

DUP; MRP1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002439.5

p.R623G

c.1867A>G

Surrounding Variants

1 paper

NM_002439.5

p.E622E

c.1866G>A

1 paper

NM_002439.5

p.R623M

c.1868G>T

1 paper

NM_002439.5

p.G624R

c.1870G>C

1 paper

NM_002439.5

p.I621T

c.1862T>C

1 paper

NM_002439.5

p.L625L

c.1875C>A

16 papers

NM_002439.5

p.D620N

c.1858G>A

1 paper

NM_002439.5

p.C626delFs

c.1877delG

1 paper

NM_002439.5

p.Y629C

c.1886A>G

1 paper

NM_002439.5

p.R616H

c.1847G>A

2 papers

NM_002439.5

p.H630D

c.1888C>G

2 papers

NM_002439.5

p.R616C

c.1846C>T

1 paper

NM_002439.5

p.H630Y

c.1888C>T