Varaico: Literature-Extracted Genetic Variants

MSH3

1,102 papers

RefSeq Summary

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch ...

Pfam Domains

MutS_Iaa 230–343UCSCMutS domain I

MutS_IIaa 366–523UCSCMutS domain II

MutS_IIIaa 540–838UCSCMutS domain III

MutS_Vaa 892–1094UCSCMutS domain V

Gene Aliases

HGNC Name

mutS homolog 3

HGNC Alias Symbols

DUP; MRP1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002439.5

p.M939L

c.2815A>C

Surrounding Variants

1 paper

NM_002439.5

p.M939L

c.2815A>T

1 paper

NM_002439.5

p.M939R

c.2816T>G

1 paper

NM_002439.5

p.G940D

c.2819G>A

1 paper

NM_002439.5

p.A942V

c.2825C>T

1 paper

NM_002439.5

p.D943G

c.2828A>G

1 paper

NM_002439.5

p.N944Y

c.2830A>T

1 paper

NM_002439.5

p.I945T

c.2834T>C

1 paper

NM_002439.5

p.I945M

c.2835A>G

1 paper

NM_002439.5

p.Y946S

c.2837A>C

1 paper

NM_002439.5

p.G948R

c.2842G>A

1 paper

NM_002439.5

p.G948R

c.2842G>C

2 papers

NM_002439.5

p.G948*

c.2842G>T