multivesicular body subunit 12B

C9orf28

FAM125B

FLJ00001

chromosome 9 open reading frame 28

family with sequence similarity 125, member B

Multivesicular body subunit 12B

ESCRT-I complex subunit MVB12B

Protein FAM125B

The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Varaico: Literature-Extracted Genetic Variants

MVB12B

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbols