Varaico: Literature-Extracted Genetic Variants

NLRC3

81 papers

RefSeq Summary

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to pr...

Pfam Domains

NACHTaa 139–305UCSCNACHT domain

WHD_NOD2aa 395–453UCSCNOD2 winged helix domain

NLRC4_HD2aa 455–582UCSCNLRC4 helical domain HD2

LRR_6aa 692–715UCSCLeucine Rich repeat

LRR_6aa 721–743UCSCLeucine Rich repeat

LRR_TMOD-LMODaa 763–847UCSCTMOD/LMOD Leucine-rich domain

Gene Aliases

HGNC Name

NLR family CARD domain containing 3

HGNC Alias Symbols

CLR16.2; FLJ00348; NOD3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_178844.4

p.G590R

c.1768G>A

Surrounding Variants

1 paper

NM_178844.4

p.G590R

c.1768G>C

1 paper

NM_178844.4

p.A599T

c.1795G>A

1 paper

NM_178844.4

p.L579L

c.1737G>A

2 papers

NM_178844.4

p.R601H

c.1802G>A

2 papers

NM_178844.4

p.V567M

c.1699G>A

1 paper

NM_178844.4

p.A559T

c.1675G>A

1 paper

NM_178844.4

p.A558A

c.1674C>G

1 paper

NM_178844.4

p.L550P

c.1649T>C

1 paper

NM_178844.4

p.Q630K

c.1888C>A

1 paper

NM_178844.4

p.A547S

c.1639G>T

1 paper

NM_178844.4

p.R640Q

c.1919G>A

1 paper

NM_178844.4

p.A535T

c.1603G>A