Varaico: Literature-Extracted Genetic Variants

NLRC3

81 papers

RefSeq Summary

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to pr...

Pfam Domains

NACHTaa 139–305UCSCNACHT domain

WHD_NOD2aa 395–453UCSCNOD2 winged helix domain

NLRC4_HD2aa 455–582UCSCNLRC4 helical domain HD2

LRR_6aa 692–715UCSCLeucine Rich repeat

LRR_6aa 721–743UCSCLeucine Rich repeat

LRR_TMOD-LMODaa 763–847UCSCTMOD/LMOD Leucine-rich domain

Gene Aliases

HGNC Name

NLR family CARD domain containing 3

HGNC Alias Symbols

CLR16.2; FLJ00348; NOD3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_178844.4

p.S205G

c.613A>G

Surrounding Variants

1 paper

NM_178844.4

p.H200L

c.599A>T

1 paper

NM_178844.4

p.R213G

c.637A>G

1 paper

NM_178844.4

p.K187R

c.560A>G

1 paper

NM_178844.4

p.T226M

c.677C>T

2 papers

NM_178844.4

p.R180Q

c.539G>A

1 paper

NM_178844.4

p.P239P

c.717A>T

1 paper

NM_178844.4

p.K241E

c.721A>G

1 paper

NM_178844.4

p.G168S

c.502G>A

1 paper

NM_178844.4

p.G165R

c.493G>C

1 paper

NM_178844.4

p.G165R

c.493G>A

1 paper

NM_178844.4

p.R160C

c.478C>T

1 paper

NM_178844.4

p.T152P

c.454A>C