Varaico: Literature-Extracted Genetic Variants

NLRC3

81 papers

RefSeq Summary

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to pr...

Pfam Domains

NACHTaa 139–305UCSCNACHT domain

WHD_NOD2aa 395–453UCSCNOD2 winged helix domain

NLRC4_HD2aa 455–582UCSCNLRC4 helical domain HD2

LRR_6aa 692–715UCSCLeucine Rich repeat

LRR_6aa 721–743UCSCLeucine Rich repeat

LRR_TMOD-LMODaa 763–847UCSCTMOD/LMOD Leucine-rich domain

Gene Aliases

HGNC Name

NLR family CARD domain containing 3

HGNC Alias Symbols

CLR16.2; FLJ00348; NOD3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_178844.4

p.A69V

c.206C>T

Surrounding Variants

2 papers

NM_178844.4

p.R67C

c.199C>T

1 paper

NM_178844.4

p.S61T

c.181T>A

1 paper

NM_178844.4

p.P78L

c.233C>T

1 paper

NM_178844.4

p.G82R

c.244G>C

1 paper

NM_178844.4

p.G82R

c.244G>A

1 paper

NM_178844.4

p.L90P

c.269T>C

1 paper

NM_178844.4

p.G95ins0

c.283_285dupGGC

1 paper

NM_178844.4

p.V109L

c.325G>T

1 paper

NM_178844.4

p.V109L

c.325G>C

2 papers

NM_178844.4

p.P53L

c.158C>T

1 paper

NM_178844.4

p.A119T

c.355G>A

1 paper

NM_178844.4

p.P50L

c.149C>T