Varaico: Literature-Extracted Genetic Variants

NR3C1

1,293 papers

RefSeq Summary

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activ...

Pfam Domains

GCRaa 26–401UCSCGlucocorticoid receptor

zf-C4aa 419–488UCSCDouble treble clef zinc finger, C4 type

Hormone_recepaa 549–741UCSCLigand-binding domain of nuclear hormone receptor

Gene Aliases

HGNC Name

nuclear receptor subfamily 3 group C member 1

HGNC Previous Symbol

GRL

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000176.3

p.N461D

c.1381A>G

Surrounding Variants

1 paper

NM_000176.3

p.R460K

c.1379G>A

1 paper

NM_000176.3

p.R460W

c.1378A>T

1 paper

NM_000176.3

p.D462A

c.1385A>C

1 paper

NM_000176.3

p.G459V

c.1376G>T

1 paper

NM_000176.3

p.C463R

c.1387T>C

1 paper

NM_000176.3

p.A458D

c.1373C>A

35 papers

NM_000176.3

p.A458T

c.1372G>A

1 paper

NM_000176.3

p.I464T

c.1391T>C

1 paper

NM_000176.3

p.C457F

c.1370G>T

2 papers

NM_000176.3

p.C457Y

c.1370G>A

3 papers

NM_000176.3

p.I465fs

c.1393_1394fs

4 papers

NM_000176.3

p.I464delFs

c.1392delG