Varaico: Literature-Extracted Genetic Variants

NTRK2

558 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–60UCSCLeucine rich repeat N-terminal domain

LRR_8aa 91–150UCSCLeucine rich repeat

LRRCT_2aa 151–195UCSCLeucine rich repeat C-terminal motif

I-setaa 197–283UCSCImmunoglobulin I-set domain

I-setaa 298–377UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 538–807UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 2

HGNC Alias Symbol

TRKB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_006180.6

p.W4C

c.12G>C

Surrounding Variants

4 papers

NM_006180.6

p.W4*

c.12G>A

1 paper

NM_006180.6

p.I5V

c.13A>G

1 paper

NM_006180.6

p.R6W

c.16A>T

1 paper

NM_006180.6

p.S3P

c.7T>C

1 paper

NM_006180.6

p.M1I

c.3G>C

1 paper

NM_006180.6

p.H8P

c.23A>C

1 paper

NM_006180.6

p.H8R

c.23A>G

1 paper

NM_006180.6

p.G9*

c.25G>T

1 paper

NM_006180.6

p.G9G

c.27A>C

1 paper

NM_006180.6

p.P10H

c.29C>A

2 papers

NM_006180.6

p.P10L

c.29C>T

3 papers

NM_006180.6

p.A11T

c.31G>A