Varaico: Literature-Extracted Genetic Variants

NTRK2

558 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–60UCSCLeucine rich repeat N-terminal domain

LRR_8aa 91–150UCSCLeucine rich repeat

LRRCT_2aa 151–195UCSCLeucine rich repeat C-terminal motif

I-setaa 197–283UCSCImmunoglobulin I-set domain

I-setaa 298–377UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 538–807UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 2

HGNC Alias Symbol

TRKB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006180.6

p.H671R

c.2012A>G

Surrounding Variants

1 paper

NM_006180.6

p.H671N

c.2011C>A

1 paper

NM_006180.6

p.H671Y

c.2011C>T

2 papers

NM_006180.6

p.I672V

c.2014A>G

2 papers

NM_006180.6

p.L670M

c.2008C>A

1 paper

NM_006180.6

p.Q674L

c.2021A>T

2 papers

NM_006180.6

p.Q675*

c.2023C>T

3 papers

NM_006180.6

p.S667W

c.2000C>G

1 paper

NM_006180.6

p.S667L

c.2000C>T

4 papers

NM_006180.6

p.Q666R

c.1997A>G

1 paper

NM_006180.6

p.I676I

c.2028C>T

1 paper

NM_006180.6

p.A677T

c.2029G>A

2 papers

NM_006180.6

p.T665M

c.1994C>T