Varaico: Literature-Extracted Genetic Variants

NTRK2

558 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–60UCSCLeucine rich repeat N-terminal domain

LRR_8aa 91–150UCSCLeucine rich repeat

LRRCT_2aa 151–195UCSCLeucine rich repeat C-terminal motif

I-setaa 197–283UCSCImmunoglobulin I-set domain

I-setaa 298–377UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 538–807UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 2

HGNC Alias Symbol

TRKB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006180.6

p.N697Y

c.2089A>T

Surrounding Variants

2 papers

NM_006180.6

p.R696K

c.2087G>A

4 papers

NM_006180.6

p.T695I

c.2084C>T

2 papers

NM_006180.6

p.G701R

c.2101G>A

2 papers

NM_006180.6

p.G701R

c.2101G>C

1 paper

NM_006180.6

p.D692N

c.2074G>A

2 papers

NM_006180.6

p.E702Q

c.2104G>C

3 papers

NM_006180.6

p.R691H

c.2072G>A

2 papers

NM_006180.6

p.E702D

c.2106G>C

2 papers

NM_006180.6

p.E702D

c.2106G>T

2 papers

NM_006180.6

p.R691C

c.2071C>T

1 paper

NM_006180.6

p.L705M

c.2113C>A

1 paper

NM_006180.6

p.L705L

c.2113C>T