Varaico: Literature-Extracted Genetic Variants

NTRK3

674 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–58UCSCLeucine rich repeat N-terminal domain

LRR_8aa 103–162UCSCLeucine rich repeat

LRRCT_2aa 163–208UCSCLeucine rich repeat C-terminal motif

igaa 217–297UCSCImmunoglobulin domain

I-setaa 316–392UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 440–617UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 3

HGNC Alias Symbol

TRKC

Papers

RefSeq ID

Protein change

DNA change

1–12 of 1017 variants

54 papers

NM_001012338.3

p.G623R

c.1867G>C

54 papers

NM_001012338.3

p.G623R

c.1867G>A

22 papers

NM_001012338.3

p.G696A

c.2087G>C

16 papers

NM_001012338.3

p.R645C

c.1933C>T

15 papers

NM_001012338.3

p.F617L

c.1849T>C

15 papers

NM_001012338.3

p.F617L

c.1851T>G

15 papers

NM_001012338.3

p.F617L

c.1851T>A

14 papers

NM_001012338.3

p.G623E

c.1868G>A

11 papers

NM_001012338.3

p.T332M

c.995C>T

9 papers

NM_001012338.3

p.T93M

c.278C>T

7 papers

NM_001012338.3

p.V21F

c.61G>T

7 papers

NM_001012338.3

p.D499N

c.1495G>A