Varaico: Literature-Extracted Genetic Variants

OAS1

149 papers

RefSeq Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cel...

Pfam Domains

NTP_transf_2aa 37–134UCSCNucleotidyltransferase domain

OAS1_Caa 163–348UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 1

HGNC Previous Symbol

OIAS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_016816.4

p.E146K

c.436G>A

Surrounding Variants

1 paper

NM_016816.4

p.E146*

c.436G>T

1 paper

NM_016816.4

p.D148A

c.443A>C

3 papers

NM_016816.4

p.E143G

c.428A>G

1 paper

NM_016816.4

p.V145delFs

c.433delG

1 paper

NM_016816.4

p.E143Q

c.427G>C

1 paper

NM_016816.4

p.G142E

c.425G>A

1 paper

NM_016816.4

p.L139F

c.415C>T

1 paper

NM_016816.4

p.S137R

c.411T>A

1 paper

NM_016816.4

p.S137R

c.411T>G

1 paper

NM_016816.4

p.S137R

c.409A>C

1 paper

NM_016816.4

p.L156L

c.466C>T

1 paper

NM_016816.4

p.V135L

c.403G>C