Varaico: Literature-Extracted Genetic Variants

OAS1

149 papers

RefSeq Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cel...

Pfam Domains

NTP_transf_2aa 37–134UCSCNucleotidyltransferase domain

OAS1_Caa 163–348UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 1

HGNC Previous Symbol

OIAS

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_016816.4

p.E183D

c.549G>C

Surrounding Variants

1 paper

NM_016816.4

p.E183D

c.549G>T

1 paper

NM_016816.4

p.G184D

c.551G>A

2 papers

NM_016816.4

p.E175K

c.523G>A

1 paper

NM_016816.4

p.I174L

c.520A>C

1 paper

NM_016816.4

p.K172R

c.515A>G

1 paper

NM_016816.4

p.F197S

c.590T>C

4 papers

NM_016816.4

p.L198V

c.592C>G

1 paper

NM_016816.4

p.K199E

c.595A>G

1 paper

NM_016816.4

p.K199R

c.596A>G

1 paper

NM_016816.4

p.K199M

c.596A>T

1 paper

NM_016816.4

p.R201S

c.601C>A

1 paper

NM_016816.4

p.P165S

c.493C>T