Varaico: Literature-Extracted Genetic Variants

OAS2

89 papers

RefSeq Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine...

Pfam Domains

OAS1_Caa 153–338UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

NTP_transf_2aa 373–474UCSCNucleotidyltransferase domain

OAS1_Caa 496–685UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 2

HGNC Previous Names

2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Papers

RefSeq ID

Protein change

DNA change

1–12 of 205 variants

4 papers

NM_002535.3

p.V290I

c.868G>A

4 papers

NM_002535.3

p.R535Q

c.1604G>A

4 papers

NM_002535.3

p.R650C

c.1948C>T

3 papers

NM_002535.3

p.Q258L

c.773A>T

2 papers

NM_002535.3

p.N154S

c.461A>G

2 papers

NM_002535.3

p.P193A

c.577C>G

2 papers

NM_002535.3

p.T229M

c.686C>T

2 papers

NM_002535.3

p.Y269C

c.806A>G

2 papers

NM_002535.3

p.R393Q

c.1178G>A

2 papers

NM_002535.3

p.F524L

c.1570T>C

2 papers

NM_002535.3

p.F524L

c.1572C>A

2 papers

NM_002535.3

p.F524L

c.1572C>G