Varaico: Literature-Extracted Genetic Variants

OAS2

89 papers

RefSeq Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine...

Pfam Domains

OAS1_Caa 153–338UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

NTP_transf_2aa 373–474UCSCNucleotidyltransferase domain

OAS1_Caa 496–685UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 2

HGNC Previous Names

2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002535.3

p.E226D

c.678G>T

Surrounding Variants

1 paper

NM_002535.3

p.E226D

c.678G>C

1 paper

NM_002535.3

p.T229A

c.685A>G

2 papers

NM_002535.3

p.T229M

c.686C>T

1 paper

NM_002535.3

p.L220P

c.659T>C

1 paper

NM_002535.3

p.E234*

c.700G>T

1 paper

NM_002535.3

p.S219T

c.655T>A

1 paper

NM_002535.3

p.Q235*

c.703C>T

1 paper

NM_002535.3

p.K213*

c.637A>T

1 paper

NM_002535.3

p.I244I

c.732T>C

1 paper

NM_002535.3

p.V248V

c.744C>T

1 paper

NM_002535.3

p.L252V

c.754C>G

3 papers

NM_002535.3

p.Q258L

c.773A>T