Varaico: Literature-Extracted Genetic Variants

OAS2

89 papers

RefSeq Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine...

Pfam Domains

OAS1_Caa 153–338UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

NTP_transf_2aa 373–474UCSCNucleotidyltransferase domain

OAS1_Caa 496–685UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 2

HGNC Previous Names

2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002535.3

p.Q627K

c.1879C>A

Surrounding Variants

1 paper

NM_002535.3

p.R632Splc

c.1895+2T>A

2 papers

NM_002535.3

p.V620M

c.1858G>A

1 paper

NM_002535.3

p.T619T

c.1857C>T

1 paper

NM_002535.3

p.Q601H

c.1803A>C

1 paper

NM_002535.3

p.Q601H

c.1803A>T

1 paper

NM_002535.3

p.A589V

c.1766C>T

1 paper

NM_002535.3

p.P584L

c.1751C>T

1 paper

NM_002535.3

p.G582V

c.1745G>T

1 paper

NM_002535.3

p.A576T

c.1726G>A

1 paper

NM_002535.3

p.Y575*

c.1725T>G

1 paper

NM_002535.3

p.A568G

c.1703C>G

2 papers

NM_002535.3

p.L563F

c.1689G>C