Varaico: Literature-Extracted Genetic Variants

OAS2

89 papers

RefSeq Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine...

Pfam Domains

OAS1_Caa 153–338UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

NTP_transf_2aa 373–474UCSCNucleotidyltransferase domain

OAS1_Caa 496–685UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 2

HGNC Previous Names

2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002535.3

p.C652S

c.1955G>C

Surrounding Variants

1 paper

NM_002535.3

p.C652S

c.1954T>A

4 papers

NM_002535.3

p.R650C

c.1948C>T

1 paper

NM_002535.3

p.K658R

c.1973A>G

1 paper

NM_002535.3

p.G646D

c.1937G>A

1 paper

NM_002535.3

p.E662K

c.1984G>A

1 paper

NM_002535.3

p.S665Y

c.1994C>A

1 paper

NM_002535.3

p.D671E

c.2013T>A

1 paper

NM_002535.3

p.D671E

c.2013T>G

1 paper

NM_002535.3

p.R632Splc

c.1895+2T>A

1 paper

NM_002535.3

p.Q627K

c.1879C>A

2 papers

NM_002535.3

p.V620M

c.1858G>A

1 paper

NM_002535.3

p.T619T

c.1857C>T