Varaico: Literature-Extracted Genetic Variants

OGG1

1,056 papers

RefSeq Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase ...

Pfam Domains

OGG_Naa 25–141UCSC8-oxoguanine DNA glycosylase, N-terminal domain

HhH-GPDaa 142–296UCSCHhH-GPD superfamily base excision DNA repair protein

HhH-GPDaa 142–299UCSCHhH-GPD superfamily base excision DNA repair protein

Gene Aliases

HGNC Name

8-oxoguanine DNA glycosylase

HGNC Alias Symbols

HMMH; HOGG1; OGH1; MUTM

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002542.6

p.T15T

c.45T>G

Surrounding Variants

1 paper

NM_002542.6

p.T15N

c.44C>A

2 papers

NM_002542.6

p.L16V

c.46C>G

1 paper

NM_002542.6

p.T15delFs

c.43_44delAC

1 paper

NM_002542.6

p.A17A

c.51C>G

1 paper

NM_002542.6

p.H13L

c.38A>T

1 paper

NM_002542.6

p.S18F

c.53C>T

1 paper

NM_002542.6

p.S18S

c.54C>A

1 paper

NM_002542.6

p.S18S

c.54C>T

10 papers

NM_002542.6

p.G12E

c.35G>A

2 papers

NM_002542.6

p.G12A

c.35G>C

4 papers

NM_002542.6

p.G12V

c.35G>T

1 paper

NM_002542.6

p.T19I

c.56C>T