Varaico: Literature-Extracted Genetic Variants

OGG1

1,056 papers

RefSeq Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase ...

Pfam Domains

OGG_Naa 25–141UCSC8-oxoguanine DNA glycosylase, N-terminal domain

HhH-GPDaa 142–296UCSCHhH-GPD superfamily base excision DNA repair protein

HhH-GPDaa 142–299UCSCHhH-GPD superfamily base excision DNA repair protein

Gene Aliases

HGNC Name

8-oxoguanine DNA glycosylase

HGNC Alias Symbols

HMMH; HOGG1; OGH1; MUTM

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002542.6

p.T67I

c.200C>T

Surrounding Variants

1 paper

NM_002542.6

p.T67A

c.199A>G

1 paper

NM_002542.6

p.L66P

c.197T>C

1 paper

NM_002542.6

p.Q68Q

c.204G>A

1 paper

NM_002542.6

p.T69S

c.205A>T

1 paper

NM_002542.6

p.T65A

c.193A>G

2 papers

NM_002542.6

p.E70K

c.208G>A

1 paper

NM_002542.6

p.E71Q

c.211G>C

1 paper

NM_002542.6

p.Q62H

c.186A>C

1 paper

NM_002542.6

p.Q62H

c.186A>T

1 paper

NM_002542.6

p.Q72H

c.216G>T

1 paper

NM_002542.6

p.D61V

c.182A>T

1 paper

NM_002542.6

p.D61N

c.181G>A