Varaico: Literature-Extracted Genetic Variants

OGG1

1,056 papers

RefSeq Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase ...

Pfam Domains

OGG_Naa 25–141UCSC8-oxoguanine DNA glycosylase, N-terminal domain

HhH-GPDaa 142–296UCSCHhH-GPD superfamily base excision DNA repair protein

HhH-GPDaa 142–299UCSCHhH-GPD superfamily base excision DNA repair protein

Gene Aliases

HGNC Name

8-oxoguanine DNA glycosylase

HGNC Alias Symbols

HMMH; HOGG1; OGH1; MUTM

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002542.6

p.G80R

c.238G>A

Surrounding Variants

1 paper

NM_002542.6

p.G80R

c.238G>C

2 papers

NM_002542.6

p.R79G

c.235C>G

1 paper

NM_002542.6

p.R79*

c.235C>T

1 paper

NM_002542.6

p.K82R

c.245A>G

1 paper

NM_002542.6

p.T76S

c.226A>T

1 paper

NM_002542.6

p.Q84delFs

c.252delG

3 papers

NM_002542.6

p.A85T

c.253G>A

16 papers

NM_002542.6

p.A85S

c.253G>T

1 paper

NM_002542.6

p.A85D

c.254C>A

1 paper

NM_002542.6

p.A85A

c.255T>G

1 paper

NM_002542.6

p.S86R

c.258C>A

1 paper

NM_002542.6

p.R87G

c.259A>G