Varaico: Literature-Extracted Genetic Variants

OGG1

1,056 papers

RefSeq Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase ...

Pfam Domains

OGG_Naa 25–141UCSC8-oxoguanine DNA glycosylase, N-terminal domain

HhH-GPDaa 142–296UCSCHhH-GPD superfamily base excision DNA repair protein

HhH-GPDaa 142–299UCSCHhH-GPD superfamily base excision DNA repair protein

Gene Aliases

HGNC Name

8-oxoguanine DNA glycosylase

HGNC Alias Symbols

HMMH; HOGG1; OGH1; MUTM

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002542.6

p.T156A

c.466A>G

Surrounding Variants

1 paper

NM_002542.6

p.I155T

c.464T>C

1 paper

NM_002542.6

p.G157S

c.469G>A

46 papers

NM_002542.6

p.R154H

c.461G>A

1 paper

NM_002542.6

p.R154C

c.460C>T

1 paper

NM_002542.6

p.R154del1

c.460_461delCGC

2 papers

NM_002542.6

p.A153T

c.457G>A

1 paper

NM_002542.6

p.I152I

c.456C>T

1 paper

NM_002542.6

p.V159G

c.476T>G

1 paper

NM_002542.6

p.N151S

c.452A>G

1 paper

NM_002542.6

p.N151I

c.452A>T

1 paper

NM_002542.6

p.E160E

c.480G>A

1 paper

NM_002542.6

p.N151Y

c.451A>T