Varaico: Literature-Extracted Genetic Variants

ORC1

187 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC ...

Pfam Domains

BAHaa 45–169UCSCBAH domain

AAAaa 530–675UCSCATPase family associated with various cellular activities (AAA)

AAA_lid_10aa 675–738UCSCAAA lid domain

WHD_ORC1aa 764–861UCSCOrigin recognition complex subunit 1 C-terminal winged HTH domain

Gene Aliases

HGNC Name

origin recognition complex subunit 1

HGNC Previous Symbol

ORC1L

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004153.4

p.P78L

c.233C>T

Surrounding Variants

2 papers

NM_004153.4

p.P78A

c.232C>G

1 paper

NM_004153.4

p.R83C

c.247C>T

12 papers

NM_004153.4

p.F89S

c.266T>C

4 papers

NM_004153.4

p.F89Y

c.266T>A

1 paper

NM_004153.4

p.R91*

c.271C>T

1 paper

NM_004153.4

p.F92L

c.274T>C

1 paper

NM_004153.4

p.F92L

c.276C>G

1 paper

NM_004153.4

p.F92L

c.276C>A

1 paper

NM_004153.4

p.C93Y

c.278G>A

1 paper

NM_004153.4

p.E94A

c.281A>C

1 paper

NM_004153.4

p.P96_A97insCA

c.286_290ins6

1 paper

NM_004153.4

p.A97S

c.289G>T