Varaico: Literature-Extracted Genetic Variants

ORC3

43 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC ...

Pfam Domains

ORC3_Naa 1–344UCSCOrigin recognition complex (ORC) subunit 3 N-terminus

ORC3_insaa 355–585UCSCOrigin recognition complex subunit 3 insertion domain

WHD_ORCaa 596–708UCSCOrigin recognition complex winged helix C-terminal

Gene Aliases

HGNC Name

origin recognition complex subunit 3

HGNC Previous Symbol

ORC3L

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_012381.4

p.H242Y

c.724C>T

Surrounding Variants

1 paper

NM_012381.4

p.I252fs

c.754_755fs

1 paper

NM_012381.4

p.H260Y

c.778C>T

2 papers

NM_012381.4

p.I236L

c.706A>C

3 papers

NM_012381.4

p.V217I

c.649G>A

1 paper

NM_012381.4

p.V217L

c.649G>C

1 paper

NM_012381.4

p.L292Q

c.875T>A

1 paper

NM_012381.4

p.S169G

c.505A>G

1 paper

NM_012381.4

p.I162T

c.485T>C

1 paper

NM_012381.4

p.Q126R

c.377A>G

1 paper

NM_012381.4

p.T112fs

c.334_335fs

1 paper

NM_012381.4

p.T112delFs

c.334delA

1 paper

NM_012381.4

p.V111I

c.331G>A