Varaico: Literature-Extracted Genetic Variants

Gene:ORC4
Variant:p.H319R

ORC4

75 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC b...

Pfam Domains

AAA_16aa 36–190UCSCAAA ATPase domain
ORC4_Caa 228–415UCSCOrigin recognition complex (ORC) subunit 4 C-terminus

Gene Aliases

HGNC Name

origin recognition complex subunit 4

HGNC Previous Symbol

ORC4L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_181741.4
p.H319R
c.956A>G
Surrounding Variants
1 paper
NM_181741.4
p.V318E
c.953T>A
2 papers
NM_181741.4
p.A292fs
c.874_875fs
4 papers
NM_181741.4
p.A292insFs
c.874_875ins4
2 papers
NM_181741.4
p.A286V
c.857C>T
1 paper
NM_181741.4
p.L285F
c.853C>T
1 paper
NM_181741.4
p.H334Y
c.1000C>T
1 paper
NM_181741.4
p.N345K
c.1035T>G
1 paper
NM_181741.4
p.N345K
c.1035T>A
1 paper
NM_181741.4
p.E352Splc
c.1054+1G>T
1 paper
NM_181741.4
p.E352Splc
c.1054+6A>G
1 paper
NM_181741.4
p.F356S
c.1067T>C
1 paper
NM_181741.4
p.V364I
c.1090G>A
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