Varaico: Literature-Extracted Genetic Variants

Gene:ORC4
Variant:p.S208*

ORC4

75 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC b...

Pfam Domains

AAA_16aa 36–190UCSCAAA ATPase domain
ORC4_Caa 228–415UCSCOrigin recognition complex (ORC) subunit 4 C-terminus

Gene Aliases

HGNC Name

origin recognition complex subunit 4

HGNC Previous Symbol

ORC4L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_181741.4
p.S208*
c.623C>G
Surrounding Variants
2 papers
NM_181741.4
p.S208*
c.623C>A
1 paper
NM_181741.4
p.Q214insFs
c.642dupG
1 paper
NM_181741.4
p.Q181*
c.541C>T
14 papers
NM_181741.4
p.Y174C
c.521A>G
1 paper
NM_181741.4
p.H166Y
c.496C>T
1 paper
NM_181741.4
p.F161del1
c.481_482delAAA
1 paper
NM_181741.4
p.D159A
c.476A>C
1 paper
NM_181741.4
p.I155L
c.463A>C
1 paper
NM_181741.4
p.R277Q
c.830G>A
1 paper
NM_181741.4
p.L283_M284Splc
c.850-1993A>G
1 paper
NM_181741.4
p.L285F
c.853C>T
2 papers
NM_181741.4
p.A286V
c.857C>T
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