Varaico: Literature-Extracted Genetic Variants

Gene:ORC4
Variant:p.L118S

ORC4

75 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC b...

Pfam Domains

AAA_16aa 36–190UCSCAAA ATPase domain
ORC4_Caa 228–415UCSCOrigin recognition complex (ORC) subunit 4 C-terminus

Gene Aliases

HGNC Name

origin recognition complex subunit 4

HGNC Previous Symbol

ORC4L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_181741.4
p.L118S
c.353T>C
Surrounding Variants
1 paper
NM_181741.4
p.Q117H
c.351G>C
1 paper
NM_181741.4
p.N100S
c.299A>G
1 paper
NM_181741.4
p.Q96R
c.287A>G
1 paper
NM_181741.4
p.N93S
c.278A>G
1 paper
NM_181741.4
p.V90M
c.268G>A
6 papers
NM_181741.4
p.N78S
c.233A>G
1 paper
NM_181741.4
p.N78T
c.233A>C
1 paper
NM_181741.4
p.I155L
c.463A>C
1 paper
NM_181741.4
p.D159A
c.476A>C
1 paper
NM_181741.4
p.F161del1
c.481_482delAAA
1 paper
NM_181741.4
p.H166Y
c.496C>T
14 papers
NM_181741.4
p.Y174C
c.521A>G
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