Varaico: Literature-Extracted Genetic Variants

ORC5

41 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC b...

Pfam Domains

AAA_16aa 7–155UCSCAAA ATPase domain

ORC5_lidaa 204–271UCSCORC5, lid domain

ORC5_Caa 302–431UCSCOrigin recognition complex (ORC) subunit 5 C-terminus

Gene Aliases

HGNC Name

origin recognition complex subunit 5

HGNC Previous Symbol

ORC5L

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002553.4

p.R131R

c.393A>G

Surrounding Variants

1 paper

NM_002553.4

p.Y129_L130delFs

c.387_390del4

1 paper

NM_002553.4

p.Y129fs

c.385_386fs

1 paper

NM_002553.4

p.N136Y

c.406A>T

1 paper

NM_002553.4

p.L124R

c.371T>G

1 paper

NM_002553.4

p.L147_A148Splc

c.442-3C>T

1 paper

NM_002553.4

p.L157F

c.469C>T

1 paper

NM_002553.4

p.F165S

c.494T>C

1 paper

NM_002553.4

p.P174L

c.521C>T

1 paper

NM_002553.4

p.R104H

c.311G>A

1 paper

NM_002553.4

p.C96S

c.287G>C

1 paper

NM_002553.4

p.C96S

c.286T>A

1 paper

NM_002553.4

p.S91F

c.272C>T