Varaico: Literature-Extracted Genetic Variants

Gene:ORC6
Variant:p.S120R

ORC6

69 papers

RefSeq Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC b...

Pfam Domains

ORC6aa 6–94UCSCOrigin recognition complex subunit 6 (ORC6)
ORC6_2ndaa 96–182UCSCORC6 second cyclin-like domain

Gene Aliases

HGNC Name

origin recognition complex subunit 6

HGNC Previous Symbol

ORC6L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_014321.4
p.S120R
c.358A>C
Surrounding Variants
2 papers
NM_014321.4
p.S120R
c.360C>A
2 papers
NM_014321.4
p.S120R
c.360C>G
1 paper
NM_014321.4
p.L118L
c.354A>G
1 paper
NM_014321.4
p.K116*
c.346A>T
1 paper
NM_014321.4
p.M113I
c.339G>A
1 paper
NM_014321.4
p.M113I
c.339G>C
1 paper
NM_014321.4
p.M113I
c.339G>T
1 paper
NM_014321.4
p.A110T
c.328G>A
1 paper
NM_014321.4
p.C107S
c.320G>C
1 paper
NM_014321.4
p.S106S
c.318C>T
1 paper
NM_014321.4
p.F105insFs
c.313_314insA
1 paper
NM_014321.4
p.L89*
c.266T>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."