Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.K47R

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002577.4
p.K47R
c.140A>G
Surrounding Variants
1 paper
NM_002577.4
p.E46A
c.137A>C
3 papers
NM_002577.4
p.K48R
c.143A>G
1 paper
NM_002577.4
p.P44P
c.132A>G
1 paper
NM_002577.4
p.R50_H51delFs
c.150_153del4
1 paper
NM_002577.4
p.V43A
c.128T>C
1 paper
NM_002577.4
p.K52E
c.154A>G
1 paper
NM_002577.4
p.S42P
c.124T>C
1 paper
NM_002577.4
p.I53I
c.159C>A
1 paper
NM_002577.4
p.I54F
c.160A>T
1 paper
NM_002577.4
p.I54N
c.161T>A
1 paper
NM_002577.4
p.S55delFs
c.165delC
1 paper
NM_002577.4
p.I56T
c.167T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."