Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.K128R

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
8 papers
NM_002577.4
p.K128R
c.383A>G
Surrounding Variants
1 paper
NM_002577.4
p.K128K
c.384G>A
1 paper
NM_002577.4
p.L127Q
c.380T>A
2 papers
NM_002577.4
p.L127L
c.379C>T
1 paper
NM_002577.4
p.Y130F
c.389A>T
1 paper
NM_002577.4
p.Y130Y
c.390C>T
1 paper
NM_002577.4
p.D131N
c.391G>A
1 paper
NM_002577.4
p.D125insFs
c.373_374insA
1 paper
NM_002577.4
p.S132A
c.394T>G
2 papers
NM_002577.4
p.L124L
c.370C>T
1 paper
NM_002577.4
p.L124delFs
c.371delT
1 paper
NM_002577.4
p.N133D
c.397A>G
1 paper
NM_002577.4
p.T134A
c.400A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."