Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.E146G

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002577.4
p.E146G
c.437A>G
Surrounding Variants
1 paper
NM_002577.4
p.E146insFs
c.436_437insA
1 paper
NM_002577.4
p.E146Splc
c.436+2T>A
1 paper
NM_002577.4
p.F142Y
c.425T>A
1 paper
NM_002577.4
p.S141R
c.423C>A
2 papers
NM_002577.4
p.S141S
c.423C>T
1 paper
NM_002577.4
p.L140Q
c.419T>A
1 paper
NM_002577.4
p.K138K
c.414A>G
1 paper
NM_002577.4
p.K138E
c.412A>G
1 paper
NM_002577.4
p.T134A
c.400A>G
1 paper
NM_002577.4
p.N133D
c.397A>G
1 paper
NM_002577.4
p.S132A
c.394T>G
1 paper
NM_002577.4
p.D131N
c.391G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."