Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.K287N

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002577.4
p.K287N
c.861G>C
Surrounding Variants
2 papers
NM_002577.4
p.P286R
c.857C>G
1 paper
NM_002577.4
p.L290P
c.869T>C
1 paper
NM_002577.4
p.I291N
c.872T>A
1 paper
NM_002577.4
p.I280L
c.838A>C
2 papers
NM_002577.4
p.Q279P
c.836A>C
4 papers
NM_002577.4
p.K278R
c.833A>G
1 paper
NM_002577.4
p.M298I
c.894G>T
1 paper
NM_002577.4
p.A276V
c.827C>T
3 papers
NM_002577.4
p.V275_A276insFs
c.825_826insA
1 paper
NM_002577.4
p.V275A
c.824T>C
2 papers
NM_002577.4
p.P304S
c.910C>T
2 papers
NM_002577.4
p.V307insFs
c.919_920insC
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."