Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.R400C

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002577.4
p.R400C
c.1198C>T
Surrounding Variants
3 papers
NM_002577.4
p.T402A
c.1204A>G
1 paper
NM_002577.4
p.T402I
c.1205C>T
1 paper
NM_002577.4
p.Q397K
c.1189C>A
2 papers
NM_002577.4
p.E396K
c.1186G>A
4 papers
NM_002577.4
p.T406M
c.1217C>T
1 paper
NM_002577.4
p.A391delFs
c.1171delG
1 paper
NM_002577.4
p.D386A
c.1157A>C
1 paper
NM_002577.4
p.T385N
c.1154C>A
5 papers
NM_002577.4
p.D425N
c.1273G>A
2 papers
NM_002577.4
p.W427insFs
c.1279_1280insA
1 paper
NM_002577.4
p.G430fs
c.1288_1289fs
7 papers
NM_002577.4
p.E435K
c.1303G>A
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