Varaico: Literature-Extracted Genetic Variants

Gene:PAK2
Variant:p.E440G

PAK2

787 papers

RefSeq Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve ...

Pfam Domains

PBDaa 73–131UCSCP21-Rho-binding domain
Pkinaseaa 249–500UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 2

HGNC Alias Symbols

PAK65; PAKgamma

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002577.4
p.E440G
c.1319A>G
Surrounding Variants
1 paper
NM_002577.4
p.G439V
c.1316G>T
1 paper
NM_002577.4
p.L444F
c.1330C>T
1 paper
NM_002577.4
p.L444P
c.1331T>C
1 paper
NM_002577.4
p.M436_V437insA
c.1306_1310ins3
7 papers
NM_002577.4
p.E435K
c.1303G>A
1 paper
NM_002577.4
p.R450G
c.1348A>G
1 paper
NM_002577.4
p.G430fs
c.1288_1289fs
2 papers
NM_002577.4
p.W427insFs
c.1279_1280insA
5 papers
NM_002577.4
p.D425N
c.1273G>A
4 papers
NM_002577.4
p.T406M
c.1217C>T
1 paper
NM_002577.4
p.T402I
c.1205C>T
3 papers
NM_002577.4
p.T402A
c.1204A>G
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."