Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005884.5

p.G3delFs

c.7delG

Surrounding Variants

1 paper

NM_005884.5

p.R5_K7del0

c.13_21del9

1 paper

NM_005884.5

p.K4M

c.11A>T

1 paper

NM_005884.5

p.E10delFs

c.29_30delAG

1 paper

NM_005884.5

p.S12F

c.35C>T

1 paper

NM_005884.5

p.P14S

c.40C>T

2 papers

NM_005884.5

p.E18V

c.53A>T

1 paper

NM_005884.5

p.H19L

c.56A>T

1 paper

NM_005884.5

p.V21M

c.61G>A

1 paper

NM_005884.5

p.H22L

c.65A>T

1 paper

NM_005884.5

p.D26N

c.76G>A

1 paper

NM_005884.5

p.H28Y

c.82C>T

1 paper

NM_005884.5

p.E29_Q30del2

c.85_89del6