Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005884.5

p.E119K

c.355G>A

Surrounding Variants

1 paper

NM_005884.5

p.E119Q

c.355G>C

1 paper

NM_005884.5

p.P121S

c.361C>T

1 paper

NM_005884.5

p.P121L

c.362C>T

1 paper

NM_005884.5

p.R110P

c.329G>C

1 paper

NM_005884.5

p.R110L

c.329G>T

2 papers

NM_005884.5

p.P108L

c.323C>T

1 paper

NM_005884.5

p.R137W

c.409C>T

2 papers

NM_005884.5

p.A139T

c.415G>A

1 paper

NM_005884.5

p.A139P

c.415G>C

1 paper

NM_005884.5

p.S99A

c.295T>G

1 paper

NM_005884.5

p.R96H

c.287G>A

1 paper

NM_005884.5

p.R96C

c.286C>T