Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005884.5

p.G186S

c.556G>A

Surrounding Variants

1 paper

NM_005884.5

p.Q189fs

c.565_566fs

1 paper

NM_005884.5

p.S181A

c.541T>G

1 paper

NM_005884.5

p.R178C

c.532C>T

1 paper

NM_005884.5

p.K177R

c.530A>G

1 paper

NM_005884.5

p.R175W

c.523C>T

1 paper

NM_005884.5

p.R203Q

c.608G>A

1 paper

NM_005884.5

p.P204Fs

c.611delinsGCFs

1 paper

NM_005884.5

p.G166V

c.497G>T

1 paper

NM_005884.5

p.S163S

c.489C>A

1 paper

NM_005884.5

p.S163F

c.488C>T

1 paper

NM_005884.5

p.S162A

c.484T>G

1 paper

NM_005884.5

p.R159S

c.477G>C