Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_005884.5

p.I417T

c.1250T>C

Surrounding Variants

1 paper

NM_005884.5

p.S429L

c.1286C>T

1 paper

NM_005884.5

p.D440N

c.1318G>A

1 paper

NM_005884.5

p.K442T

c.1325A>C

1 paper

NM_005884.5

p.D444A

c.1331A>C

1 paper

NM_005884.5

p.V407I

c.1219G>A

1 paper

NM_005884.5

p.Y385H

c.1153T>C

1 paper

NM_005884.5

p.N383Y

c.1147A>T

1 paper

NM_005884.5

p.Y373F

c.1118A>T

2 papers

NM_005884.5

p.F461V

c.1381T>G

2 papers

NM_005884.5

p.S474A

c.1420T>G

1 paper

NM_005884.5

p.S474*

c.1421C>A

1 paper

NM_005884.5

p.S474L

c.1421C>T