Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005884.5

p.S474A

c.1420T>G

Surrounding Variants

1 paper

NM_005884.5

p.S474*

c.1421C>A

1 paper

NM_005884.5

p.S474L

c.1421C>T

1 paper

NM_005884.5

p.V476I

c.1426G>A

1 paper

NM_005884.5

p.P479L

c.1436C>T

1 paper

NM_005884.5

p.W481*

c.1442G>A

1 paper

NM_005884.5

p.W481*

c.1443G>A

1 paper

NM_005884.5

p.M482K

c.1445T>A

2 papers

NM_005884.5

p.F461V

c.1381T>G

1 paper

NM_005884.5

p.S500L

c.1499C>T

1 paper

NM_005884.5

p.D510D

c.1530C>T

1 paper

NM_005884.5

p.G511R

c.1531G>A

1 paper

NM_005884.5

p.G511R

c.1531G>C