Varaico: Literature-Extracted Genetic Variants

Gene:PAK5
Variant:p.D421N

PAK5

200 papers

RefSeq Summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulati...

Pfam Domains

PBDaa 10–67UCSCP21-Rho-binding domain
Pkinaseaa 449–700UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 5

HGNC Previous Symbol

PAK7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_177990.4
p.D421N
c.1261G>A
Surrounding Variants
1 paper
NM_177990.4
p.S420delins
c.1259_1260delinsTT
1 paper
NM_177990.4
p.S420F
c.1259C>T
1 paper
NM_177990.4
p.S420P
c.1258T>C
1 paper
NM_177990.4
p.Q422Q
c.1266G>A
1 paper
NM_177990.4
p.Q423E
c.1267C>G
1 paper
NM_177990.4
p.Q423Q
c.1269G>A
1 paper
NM_177990.4
p.P424S
c.1270C>T
1 paper
NM_177990.4
p.P413P
c.1239G>A
1 paper
NM_177990.4
p.S409R
c.1227C>G
1 paper
NM_177990.4
p.S409R
c.1227C>A
1 paper
NM_177990.4
p.S409R
c.1225A>C
1 paper
NM_177990.4
p.R433L
c.1298G>T
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