Varaico: Literature-Extracted Genetic Variants

Gene:PAK5
Variant:p.D140N

PAK5

200 papers

RefSeq Summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulati...

Pfam Domains

PBDaa 10–67UCSCP21-Rho-binding domain
Pkinaseaa 449–700UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 5

HGNC Previous Symbol

PAK7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_177990.4
p.D140N
c.418G>A
Surrounding Variants
1 paper
NM_177990.4
p.A139P
c.415G>C
1 paper
NM_177990.4
p.T142M
c.425C>T
1 paper
NM_177990.4
p.D136D
c.408T>C
2 papers
NM_177990.4
p.E144K
c.430G>A
1 paper
NM_177990.4
p.Q130H
c.390G>T
1 paper
NM_177990.4
p.Q130H
c.390G>C
1 paper
NM_177990.4
p.K149N
c.447G>T
1 paper
NM_177990.4
p.K149N
c.447G>C
1 paper
NM_177990.4
p.T127_Q130ins1
c.380_388dup9
1 paper
NM_177990.4
p.G124G
c.372C>A
1 paper
NM_177990.4
p.L156R
c.467T>G
1 paper
NM_177990.4
p.Y159F
c.476A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."