Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.Q463E

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.Q463E
c.1387C>G
Surrounding Variants
1 paper
NM_002582.4
p.Q463R
c.1388A>G
1 paper
NM_002582.4
p.Y462C
c.1385A>G
1 paper
NM_002582.4
p.L464F
c.1390C>T
1 paper
NM_002582.4
p.L461P
c.1382T>C
1 paper
NM_002582.4
p.L461H
c.1382T>A
1 paper
NM_002582.4
p.F465L
c.1393T>C
1 paper
NM_002582.4
p.L461V
c.1381C>G
1 paper
NM_002582.4
p.F465L
c.1395C>G
1 paper
NM_002582.4
p.L464insFs
c.1391dupT
1 paper
NM_002582.4
p.F465L
c.1395C>A
1 paper
NM_002582.4
p.D460Y
c.1378G>T
1 paper
NM_002582.4
p.D460H
c.1378G>C
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