Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.K454E

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.K454E
c.1360A>G
Surrounding Variants
1 paper
NM_002582.4
p.K454R
c.1361A>G
1 paper
NM_002582.4
p.P453R
c.1358C>G
1 paper
NM_002582.4
p.E455*
c.1363G>T
2 papers
NM_002582.4
p.E455K
c.1363G>A
1 paper
NM_002582.4
p.P453S
c.1357C>T
1 paper
NM_002582.4
p.E455V
c.1364A>T
1 paper
NM_002582.4
p.E455G
c.1364A>G
1 paper
NM_002582.4
p.F452S
c.1355T>C
1 paper
NM_002582.4
p.F452V
c.1354T>G
1 paper
NM_002582.4
p.T451S
c.1351A>T
1 paper
NM_002582.4
p.K457E
c.1369A>G
1 paper
NM_002582.4
p.T451A
c.1351A>G
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."