Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.H446D

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.H446D
c.1336C>G
Surrounding Variants
1 paper
NM_002582.4
p.H446N
c.1336C>A
1 paper
NM_002582.4
p.D445E
c.1335T>G
1 paper
NM_002582.4
p.D445E
c.1335T>A
1 paper
NM_002582.4
p.H446R
c.1337A>G
1 paper
NM_002582.4
p.Q441_D445del5
c.1321_1334del15
1 paper
NM_002582.4
p.V447I
c.1339G>A
1 paper
NM_002582.4
p.R444H
c.1331G>A
5 papers
NM_002582.4
p.R444C
c.1330C>T
1 paper
NM_002582.4
p.L448F
c.1342C>T
1 paper
NM_002582.4
p.R444S
c.1330C>A
1 paper
NM_002582.4
p.R444_V447del4
c.1330_1340del12
1 paper
NM_002582.4
p.K443R
c.1328A>G
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