Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.L440Splc

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.L440Splc
c.1319-2A>C
Surrounding Variants
1 paper
NM_002582.4
p.L440Splc
c.1319-2A>T
2 papers
NM_002582.4
p.L440Splc
c.1319-2A>G
1 paper
NM_002582.4
p.L440Splc
c.1319-1G>T
1 paper
NM_002582.4
p.L440fs
c.1318_1319fs
1 paper
NM_002582.4
p.L440L
c.1320G>A
1 paper
NM_002582.4
p.Q441E
c.1321C>G
1 paper
NM_002582.4
p.Q441K
c.1321C>A
1 paper
NM_002582.4
p.P442A
c.1324C>G
1 paper
NM_002582.4
p.P442R
c.1325C>G
1 paper
NM_002582.4
p.K443R
c.1328A>G
5 papers
NM_002582.4
p.R444C
c.1330C>T
1 paper
NM_002582.4
p.R444S
c.1330C>A
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