Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.Y381F

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.Y381F
c.1142A>T
Surrounding Variants
1 paper
NM_002582.4
p.D382N
c.1144G>A
1 paper
NM_002582.4
p.E378_A379del2
c.1132_1136del6
2 papers
NM_002582.4
p.D382A
c.1145A>C
8 papers
NM_002582.4
p.A383V
c.1148C>T
1 paper
NM_002582.4
p.A383G
c.1148C>G
1 paper
NM_002582.4
p.A379S
c.1135G>T
1 paper
NM_002582.4
p.E378D
c.1134G>T
1 paper
NM_002582.4
p.E378D
c.1134G>C
3 papers
NM_002582.4
p.Y384C
c.1151A>G
2 papers
NM_002582.4
p.E378K
c.1132G>A
1 paper
NM_002582.4
p.I385V
c.1153A>G
1 paper
NM_002582.4
p.T386A
c.1156A>G
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