Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.R349W

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
7 papers
NM_002582.4
p.R349W
c.1045C>T
Surrounding Variants
1 paper
NM_002582.4
p.R349Q
c.1046G>A
1 paper
NM_002582.4
p.K348M
c.1043A>T
1 paper
NM_002582.4
p.L350V
c.1048T>G
1 paper
NM_002582.4
p.L350I
c.1048T>A
1 paper
NM_002582.4
p.K348E
c.1042A>G
2 papers
NM_002582.4
p.A344_E347del4
c.1030_1040del12
1 paper
NM_002582.4
p.L350F
c.1050A>T
1 paper
NM_002582.4
p.L350F
c.1050A>C
1 paper
NM_002582.4
p.L346W
c.1037T>G
1 paper
NM_002582.4
p.L346V
c.1036T>G
2 papers
NM_002582.4
p.E352fs
c.1054_1055fs
1 paper
NM_002582.4
p.E352D
c.1056G>T
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