Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.E345G

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.E345G
c.1034A>G
Surrounding Variants
1 paper
NM_002582.4
p.L346V
c.1036T>G
1 paper
NM_002582.4
p.L346W
c.1037T>G
1 paper
NM_002582.4
p.A344V
c.1031C>T
1 paper
NM_002582.4
p.A344G
c.1031C>G
1 paper
NM_002582.4
p.A344E
c.1031C>A
1 paper
NM_002582.4
p.A344fs
c.1030_1031fs
1 paper
NM_002582.4
p.L343P
c.1028T>C
1 paper
NM_002582.4
p.L343delFs
c.1027delG
1 paper
NM_002582.4
p.K348E
c.1042A>G
2 papers
NM_002582.4
p.A344_E347del4
c.1030_1040del12
1 paper
NM_002582.4
p.S342F
c.1025C>T
1 paper
NM_002582.4
p.S342C
c.1025C>G
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