Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.Q261*

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.Q261*
c.781C>T
Surrounding Variants
1 paper
NM_002582.4
p.Q261P
c.782A>C
2 papers
NM_002582.4
p.Q261_E262Splc
c.783+1G>A
1 paper
NM_002582.4
p.E260K
c.778G>A
1 paper
NM_002582.4
p.Q261_E262Splc
c.783+2T>G
1 paper
NM_002582.4
p.K259E
c.775A>G
1 paper
NM_002582.4
p.A258V
c.773C>T
1 paper
NM_002582.4
p.H257R
c.770A>G
1 paper
NM_002582.4
p.Q255del1
c.763_765delCTG
1 paper
NM_002582.4
p.Q254L
c.761A>T
2 papers
NM_002582.4
p.Q254*
c.760C>T
1 paper
NM_002582.4
p.Q254E
c.760C>G
1 paper
NM_002582.4
p.E253K
c.757G>A
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