Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.R251fs

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.R251fs
c.751_752fs
Surrounding Variants
1 paper
NM_002582.4
p.R251I
c.752G>T
4 papers
NM_002582.4
p.R251delFs
c.751delT
1 paper
NM_002582.4
p.R252G
c.754A>G
1 paper
NM_002582.4
p.R252K
c.755G>A
1 paper
NM_002582.4
p.R251_R252delFs
c.753_754delTT
1 paper
NM_002582.4
p.R251G
c.751A>G
4 papers
NM_002582.4
p.R251fs
c.751_752fs
1 paper
NM_002582.4
p.R252S
c.756A>T
1 paper
NM_002582.4
p.R252S
c.756A>C
1 paper
NM_002582.4
p.E253K
c.757G>A
1 paper
NM_002582.4
p.E253fs
c.757_758fs
1 paper
NM_002582.4
p.K250*
c.748A>T
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